Is Stem Cell Therapy (BMC) Safe? Published Research

Every published BMC study must assess both safety and efficacy of the therapy. In the 30+ years of BMC use in orthopedics, thousands of studies have been published, each affirming the safety of BMC therapy. Below are just a few of those studies showing the extensive history of safe BMC intervention in orthopedic applications.

Treatment of Hemophilic Ankle Arthropathy with One-Step Arthroscopic Bone Marrow–Derived Cells Transplantation

Buda R, Cavallo M, Castagnini F, et al.

Cartilage. 2015;6(3):150-155. doi:10.1177/1947603515574286


Anterior cruciate ligament tears treated with percutaneous injection of autologous bone marrow nucleated cells: a case series

Centeno CJ, Pitts J, Al-Sayegh H, Freeman MD

J Pain Res (2015) 8:437–447. doi:10.2147/JPR.S86244


Efficacy of autologous bone marrow concentrate for knee osteoarthritis with and without adipose graft.

Centeno C, Pitts J, Al-Sayegh H, Freeman M

Bio Med Res Int (2014):370621–370629.doi:10.1155/2014/370621


Treatment of osteonecrosis with autologous bone marrow grafting

Hernigou P, Beaujean F

Clin Orthop Relat Res (2002)  405(405):14–23. doi:10.1097/00003086-200212000-00003


Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells

Hernigou P, Poignard A, Beaujean F, Rouard H

J Bone Joint Surg (2005) (Am Vol) 87(7):1430. doi:10.2106/JBJS.D.02215


Percutaneous injection of bone marrow mesenchymal stem cells for ankle non-unions decreases complications in patients with diabetes

Hernigou P, Guissou I, Homma Y, et al.

Int Orthop. 2015;39(8):1639-1643. doi:10.1007/s00264-015-2738-2


Cancer risk is not increased inpatients treated for orthopaedic diseases with autologous bone marrow cell concentrate

Hernigou P, Homma Y, Flouzat-Lachaniette C-H, Poignard A,Chevallier N, Rouard H

J Bone Joint Surg (2013) (Am Vol) 95(24):2215. doi:10.2106/JBJS.M.


Cell therapy of hip osteonecrosis with autologous bone marrow grafting

Hernigou P, Poignard A, Zilber S, Rouard H

Ind J Orthop (2009)  43(1):40–45. doi:10.4103/0019-5413.45322



Percutaneous injection of autologous bone marrow concentrate cells significantly reduces lumbar discogenic pain through 12 months

Pettine KA, Murphy MB, Suzuki RK, Sand TT.

Stem Cells. 2015;33(1):146-156. doi:10.1002/stem.1845