Is PRP Safe? Published Research

All PRP studies assess the safety of the therapy, and to date none have concluded it poses any additional risk in comparison to other common treatments like steroid shots or viscosupplementation.

Though thousands of studies have come to the same conclusions, we’ve collected a small sampling of publications confirming the safety of PRP therapy below:

Platelet-rich plasma in orthopedic therapy: a comparative systematic review of clinical and experimental data in equine and human musculoskeletal lesions

Brossi PM, Moreira JJ, Machado TS, Baccarin RY.

BMC Vet Res. 2015;11:98. doi: 10.1186/s12917-015-0403-z.


IOC consensus paper on the use of platelet-rich plasma in sports medicine

Engebretsen L, Steffen K, Alsousou J, Anitua E, Bachi N.

Br J Sports Med. 2010;44:1072–81.


Sample size and statistical power of randomized, controlled trials in orthopaedics

Freedman KB, Back S, Bernstein J.

J Bone Joint Surg (Br) 2001;83:397–402.



Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life

Wang-Saegusa A, Cugat R, Ares O, Seijas R, Cuscó X, Garcia-Balletbó M.

Arch Orthop Trauma Surg. 2011;131:311–7.